Logic Gating by Macrocycle Displacement Using a Double-Stranded DNA [3]Rotaxane Shuttle

Molecular interlocked systems with mechanically trapped components can serve as versatile building blocks for dynamic nanostructures. Here we report the synthesis of unprecedented double‐stranded (ds) DNA [2]‐ and [3]rotaxanes with two distinct stations for the hybridization of the macrocycles on th...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2014-09, Vol.53 (39), p.10372-10376
Main Authors: Lohmann, Finn, Weigandt, Johannes, Valero, Julián, Famulok, Michael
Format: Article
Language:English
Subjects:
Algorithms
Atomic force microscopy
Cascades
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA computing
DNA rotaxanes
Dynamical systems
Dynamics
Isomerism
Logic
Macrocyclic compounds
Microscopy, Atomic Force
molecular devices
Nanoengineering
Nanostructure
nanostructures
Nanostructures - chemistry
Nucleic Acid Hybridization
Oligodeoxyribonucleotides - chemistry
Rotaxanes - chemistry
Stations
Ultraviolet Rays
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Summary:Molecular interlocked systems with mechanically trapped components can serve as versatile building blocks for dynamic nanostructures. Here we report the synthesis of unprecedented double‐stranded (ds) DNA [2]‐ and [3]rotaxanes with two distinct stations for the hybridization of the macrocycles on the axle. In the [3]rotaxane, the release and migration of the “shuttle ring” mobilizes a second macrocycle in a highly controlled fashion. Different oligodeoxynucleotides (ODNs) employed as inputs induce structural changes in the system that can be detected as diverse logically gated output signals. We also designed nonsymmetrical [2]rotaxanes which allow unambiguous localization of the position of the macrocycle by use of atomic force microscopy (AFM). Either light irradiation or the use of fuel ODNs can drive the threaded macrocycle to the desired station in these shuttle systems. The DNA nanostructures introduced here constitute promising prototypes for logically gated cargo delivery and release shuttles. Shuttling on a DNA track: A cascade macrocycle‐displacement and ‐dethreading reaction triggered by light and toehold release oligodeoxynucleotides is used to assemble a logic AND gate on a double‐stranded DNA [3]rotaxane. Such structures may find applications in nanoengineering, DNA computing, and even nanomedicine.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201405447