Catalytic Cleavage of Ether CO Bonds by Pincer Iridium Complexes

The development of efficient catalytic methods to cleave the relatively unreactive CO bonds of ethers remains an important challenge in catalysis. Building on our group’s recent work, we report the dehydroaryloxylation of aryl alkyl ethers using pincer iridium catalysts. This method represents a ra...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2014-09, Vol.53 (38), p.10160-10163
Main Authors: Haibach, Michael C., Lease, Nicholas, Goldman, Alan S.
Format: Article
Language:English
Subjects:
Aromatic compounds
Catalysis
Catalysts
Cleavage
Construction
Conversion
CH activation
CO cleavage
Ethers
Ethers - chemistry
Iridium
Iridium - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Phenols
pincer ligands
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Summary:The development of efficient catalytic methods to cleave the relatively unreactive CO bonds of ethers remains an important challenge in catalysis. Building on our group’s recent work, we report the dehydroaryloxylation of aryl alkyl ethers using pincer iridium catalysts. This method represents a rare fully atom‐economical method for ether CO bond cleavage. A catalyst for ether direction: Cleavage of the alkyl CO bond of aryl ethers is catalyzed by pincer Ir catalysts, without the need for additional reagents, including H2. The corresponding phenols are generated in up to 99 % conversion, with reaction times as short as 1 hour.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201402576