Direct Access to Benzo[b]furans through Palladium-Catalyzed Oxidative Annulation of Phenols and Unactivated Internal Alkynes

2,3‐Disubstituted benzo[b]furans are prepared in one step from commercially available phenols and readily accessible unactivated internal alkynes (see scheme). This Pd‐catalyzed oxidative annulation has a broad substrate scope and allows access to a wide range of benzo[b]furans.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-04, Vol.52 (17), p.4607-4612
Main Authors: Kuram, Malleswara Rao, Bhanuchandra, M., Sahoo, Akhila K.
Format: Article
Language:English
Subjects:
Accessibility
Alkynes
Alkynes - chemistry
benzo[b]furans
Benzofurans - chemical synthesis
Benzofurans - chemistry
Catalysis
Chemical reactions
Molecular Structure
Organic chemistry
Oxidation-Reduction
oxidative annulation
Palladium
Palladium - chemistry
Phenols
Phenols - chemistry
regioselectivity
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Description
Summary:2,3‐Disubstituted benzo[b]furans are prepared in one step from commercially available phenols and readily accessible unactivated internal alkynes (see scheme). This Pd‐catalyzed oxidative annulation has a broad substrate scope and allows access to a wide range of benzo[b]furans.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201210217