Total Synthesis and Structural Revision of ViridicatumtoxinB

Will the real viridicatumtoxinB please stand up: The total synthesis of viridicatumtoxinB resulted in its structural revision and opens the way for analogue construction and biological evaluation of this complex tetracycline-like antibiotic. The highly convergent strategy employed allows for swift c...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-08, Vol.52 (33), p.8736-8741
Main Authors: Nicolaou, K. C, Nilewski, Christian, Hale, Christopher R. H, Ioannidou, Heraklidia A, ElMarrouni, Abdelatif, Koch, Lizanne G
Format: Article
Language:English
Subjects:
Analogue
Antibiotics
Biological
Construction
Stands
Strategy
Supports
Synthesis
Online Access:Get full text
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Summary:Will the real viridicatumtoxinB please stand up: The total synthesis of viridicatumtoxinB resulted in its structural revision and opens the way for analogue construction and biological evaluation of this complex tetracycline-like antibiotic. The highly convergent strategy employed allows for swift construction of the entire carbocyclic framework of the molecule.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201304691