Rhodium-Catalyzed Asymmetric Synthesis of Spirosilabifluorene Derivatives

Si goes chiral: Treatment of a bis(biphenyl)silane with a catalytic amount of a rhodium complex gave a spirosilabifluorene bearing a quaternary silicon atom. By using a rhodium catalyst with a chiral phosphine ligand (see scheme), asymmetric dehydrogenative cyclization proceeded to give chiral deriv...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-01, Vol.52 (5), p.1520-1522
Main Authors: Kuninobu, Yoichiro, Yamauchi, Kanae, Tamura, Naoya, Seiki, Takayuki, Takai, Kazuhiko
Format: Article
Language:English
Subjects:
asymmetric synthesis
Asymmetry
Catalysts
CH activation
Derivatives
Ligands
Phosphines
Rhodium
Silicon
Synthesis
synthetic methods
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Summary:Si goes chiral: Treatment of a bis(biphenyl)silane with a catalytic amount of a rhodium complex gave a spirosilabifluorene bearing a quaternary silicon atom. By using a rhodium catalyst with a chiral phosphine ligand (see scheme), asymmetric dehydrogenative cyclization proceeded to give chiral derivatives in good yields and enantioselectivities.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207723