Enantioselective Diels-Alder Reactions with G-Quadruplex DNA-Based Catalysts

DNA in command: An enantioselective Diels–Alder reaction can be achieved using human telomeric G‐quadruplex DNA‐based catalysts. The absolute configuration of the product can be reversed when the conformation of G‐quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate a...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-09, Vol.51 (37), p.9352-9355
Main Authors: Wang, Changhao, Jia, Guoqing, Zhou, Jun, Li, Yinghao, Liu, Yan, Lu, Shengmei, Li, Can
Format: Article
Language:English
Subjects:
asymmetric catalysis
Catalysis
Catalysts
Commands
cycloaddition
Cycloaddition Reaction
Deoxyribonucleic acid
Diels-Alder reaction
Diels-Alder reactions
DNA
G-Quadruplexes
Gene sequencing
Human
Humans
Kinetics
Nucleic Acid Conformation
sequence-dependence
Stereoisomerism
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Summary:DNA in command: An enantioselective Diels–Alder reaction can be achieved using human telomeric G‐quadruplex DNA‐based catalysts. The absolute configuration of the product can be reversed when the conformation of G‐quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels–Alder reaction were found to be dependent on the DNA sequence.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201204850