Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of [alpha]-Imino Esters with Isocyanoacetate

Presented herein is a new complexity-generating method in which both functionalities of [alpha]-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized [alpha],[beta]-diamino esters an...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2014-05, Vol.53 (21), p.5435-5439
Main Authors: Shao, Pan-Lin, Liao, Jia-Yu, Ho, Yee Ann, Zhao, Yu
Format: Article
Language:English
Subjects:
Asymmetry
Beta
Catalysis
Catalysts
Esters
Silver
Synthesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Presented herein is a new complexity-generating method in which both functionalities of [alpha]-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized [alpha],[beta]-diamino esters and imidazolinium salts in high diastereo- and enantiopurity. [PUBLICATION ABSTRACT]
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201402788