Temperature-Responsive "Catch and Release" of Proteins by using Multifunctional Polymer-Based Nanoparticles

Catch me if you can: Multifunctional, polymer‐based nanoparticles that are capable of temperature‐responsive “catch‐and‐release” of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding se...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-03, Vol.51 (10), p.2405-2408
Main Authors: Yoshimatsu, Keiichi, Lesel, Benjamin K., Yonamine, Yusuke, Beierle, John M., Hoshino, Yu, Shea, Kenneth J.
Format: Article
Language:English
Subjects:
Binding
molecular recognition
Molecular Structure
Monomers
Muramidase - chemistry
Nanoparticles
Nanoparticles - chemistry
phase transitions
polymers
Polymers - chemistry
Proteins
Proteins - chemistry
Selectivity
Temperature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Catch me if you can: Multifunctional, polymer‐based nanoparticles that are capable of temperature‐responsive “catch‐and‐release” of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201107797