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Temperature-Responsive "Catch and Release" of Proteins by using Multifunctional Polymer-Based Nanoparticles

Catch me if you can: Multifunctional, polymer‐based nanoparticles that are capable of temperature‐responsive “catch‐and‐release” of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding se...

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Published in:Angewandte Chemie International Edition 2012-03, Vol.51 (10), p.2405-2408
Main Authors: Yoshimatsu, Keiichi, Lesel, Benjamin K., Yonamine, Yusuke, Beierle, John M., Hoshino, Yu, Shea, Kenneth J.
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Language:English
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container_title Angewandte Chemie International Edition
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creator Yoshimatsu, Keiichi
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description Catch me if you can: Multifunctional, polymer‐based nanoparticles that are capable of temperature‐responsive “catch‐and‐release” of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.
doi_str_mv 10.1002/anie.201107797
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ispartof Angewandte Chemie International Edition, 2012-03, Vol.51 (10), p.2405-2408
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source Wiley-Blackwell Read & Publish Collection
subjects Binding
molecular recognition
Molecular Structure
Monomers
Muramidase - chemistry
Nanoparticles
Nanoparticles - chemistry
phase transitions
polymers
Polymers - chemistry
Proteins
Proteins - chemistry
Selectivity
Temperature
title Temperature-Responsive "Catch and Release" of Proteins by using Multifunctional Polymer-Based Nanoparticles
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