NeuO: a Fluorescent Chemical Probe for Live Neuron Labeling

To address existing limitations in live neuron imaging, we have developed NeuO, a novel cell‐permeable fluorescent probe with an unprecedented ability to label and image live neurons selectively over other cells in the brain. NeuO enables robust live neuron imaging and isolation in vivo and in vitro...

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Bibliographic Details
Published in:Angewandte Chemie 2015-02, Vol.127 (8), p.2472-2476
Main Authors: Er, Jun Cheng, Leong, Cheryl, Teoh, Chai Lean, Yuan, Qiang, Merchant, Paolomi, Dunn, Matthew, Sulzer, David, Sames, Dalibor, Bhinge, Akshay, Kim, Dongyoon, Kim, Seong-Min, Yoon, Myung-Han, Stanton, Lawrence W., Je, Shawn H., Yun, Seong-Wook, Chang, Young-Tae
Format: Article
Language:English
Subjects:
BODIPY
Brain
Chemistry
Fluoreszenzsonden
Imaging
Kontrastmittel
Labels
Lebende Neuronen
Marking
Neurons
Versatility
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Summary:To address existing limitations in live neuron imaging, we have developed NeuO, a novel cell‐permeable fluorescent probe with an unprecedented ability to label and image live neurons selectively over other cells in the brain. NeuO enables robust live neuron imaging and isolation in vivo and in vitro across species; its versatility and ease of use sets the basis for its development in a myriad of neuronal targeting applications. Die selektive Markierung von lebenden Neuronen gegenüber anderen Gehirnzellen wurde mit einer neuen Fluoreszenzsonde, NeuO, erreicht. Sie ermöglicht die stabile In‐vivo‐ und In‐vitro‐Bildgebung lebender Neuronen in beliebigen Spezies und schafft eine Grundlage für Studien der Neuronenentwicklung und ‐degeneration.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201408614