Electrostatic Assembly/Disassembly of Nanoscaled Colloidosomes for Light-Triggered Cargo Release

Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2015-06, Vol.54 (23), p.6804-6808
Main Authors: Li, Song, Moosa, Basem A., Croissant, Jonas G., Khashab, Niveen M.
Format: Article
Language:English
Subjects:
Assembly
Charging
colloidosomes
Colloids
Derivatives
Electrostatics
emulsions
Encapsulation
Light irradiation
Nanostructure
organosilica compounds
release
silica nanoparticles
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Summary:Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large‐cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene‐alkoxysilane [NB; 3‐nitro‐N‐(3‐(triethoxysilyl)propyl)‐4‐(((3‐(triethoxysilyl)propyl)‐amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light‐triggered release of cargos. Nanocapsules for large cargos: Nanoscaled colloidosomes were designed by electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces, arising from different contents of a bridged nitrophenylene–alkoxysilane derivative in the silica. The positive charge was reversed by light irradiation because of the photoreaction of nitrophenylene moieties.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201501615