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Spiroboronate Si-rhodamine as a near-infrared probe for imaging lysosomes based on the reversible ring-opening process

A cyclic boronate structure was incorporated into Si-rhodamine to design a pH-activatable near-infrared (NIR) probe based on the reversible ring-opening process triggered by H(+). The probe showed general suitability of specific labelling of acidic lysosomes and tracking their pH changes in living c...

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Published in:	Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (47), p.9608-9611
Main Authors:	Zhu, Weiwei, Chai, Xiaoyun, Wang, Baogang, Zou, Yan, Wang, Ting, Meng, Qingguo, Wu, Qiuye
Format:	Article
Language:	English
Subjects:	Animals Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Hep G2 Cells Humans Hydrogen-Ion Concentration Image Processing, Computer-Assisted - methods Imaging Labelling Lysosomes Lysosomes - metabolism Molecular Imaging PC12 Cells Rats Rhodamines - chemistry Rhodamines - metabolism Spectrometry, Fluorescence Spectroscopy, Near-Infrared Spironolactone - chemistry Spironolactone - metabolism Tracking
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creator	Zhu, Weiwei Chai, Xiaoyun Wang, Baogang Zou, Yan Wang, Ting Meng, Qingguo Wu, Qiuye
description	A cyclic boronate structure was incorporated into Si-rhodamine to design a pH-activatable near-infrared (NIR) probe based on the reversible ring-opening process triggered by H(+). The probe showed general suitability of specific labelling of acidic lysosomes and tracking their pH changes in living cells.
doi_str_mv	10.1039/c5cc02496j
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subjects	Animals Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Hep G2 Cells Humans Hydrogen-Ion Concentration Image Processing, Computer-Assisted - methods Imaging Labelling Lysosomes Lysosomes - metabolism Molecular Imaging PC12 Cells Rats Rhodamines - chemistry Rhodamines - metabolism Spectrometry, Fluorescence Spectroscopy, Near-Infrared Spironolactone - chemistry Spironolactone - metabolism Tracking
title	Spiroboronate Si-rhodamine as a near-infrared probe for imaging lysosomes based on the reversible ring-opening process
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