Beyond Acid Strength in Zeolites: Soft Framework Counteranions for Stabilization of Carbocations on Zeolites and Its Implication in Organic Synthesis

• Published in: Angewandte Chemie International Edition 2015-05, Vol.54 (19), p.5658-5661
• Main Authors: Cabrero-Antonino, Jose R., Leyva-Pérez, Antonio, Corma, Avelino
• Format: Article
• Language: English
• Subjects: Cancer; carbocations; Colon; cycloaddition reactions; heterogeneous catalysis; Inhibition; Lewis acid; Molecular weight; Phenols; propargyl alcohols; Strength; Surface chemistry; Zeolites
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201500864

The generation of a carbocation with an acid depends not only on the acid strength but also on the ability of the counteranion to stabilize the positive charge left behind. Here we report that despite their relatively weak acidity, zeolites are able to generate and stabilize medium‐size (molecular weight ≈300 Da) delocalized carbocations on their surface under mild reaction conditions, as it can be done by strong Brønsted or Lewis acids in solution. The zeolite thus acts as a soft macroanion, prolonging the lifetime of the carbocation sufficiently to perform multifunctionalization reactions with amides, thioamides, and phenols, with high yield and selectivity. Biological studies show that some of the products obtained here present significant inhibition activity against colon cancer cells, illustrating the new possibilities of zeolites to prepare complex organic molecules. Stabilized carbocations: Zeolites are able to generate and stabilize medium‐size (molecular weight ≈300 Da) delocalized carbocations on their surface under mild conditions to perform multifunctionalization reactions with catalytic activities comparable to that of strong homogenous Brønsted acids. Some of the products obtained here exhibit significant inhibition percentages against colon cancer cells.