Glycomics for Drug Discovery: Metabolic Perturbation in Androgen-Independent Prostate Cancer Cells Induced by Unnatural Hexosamine Mimics

Inhibited: N‐acetylglucosamine (GlcNAc) derivatives with a fluorine atom at the C4 position (2–4) were synthesized, and their ability to inhibit cancer‐cell growth was investigated. The administration of these 4F‐GlcNAc derivatives to cells led to the unnatural sugar nucleotide 1. Furthermore, N‐gly...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-04, Vol.51 (14), p.3386-3390
Main Authors: Nishimura, Shin-Ichiro, Hato, Megumi, Hyugaji, Satoshi, Feng, Fei, Amano, Maho
Format: Article
Language:English
Subjects:
Acetylglucosamine - chemical synthesis
Acetylglucosamine - chemistry
Acetylglucosamine - toxicity
Androgens - metabolism
Apoptosis - drug effects
Cancer
Carbohydrate Sequence
carbohydrates
Cell Line, Tumor
Derivatives
Drug Evaluation, Preclinical
Drugs
Fluorine
Fluorine - chemistry
Glycomics
Glycosylation
hexosamine pathway
Humans
Male
Molecular Sequence Data
N-glycans
Nucleotides
Perturbation methods
Prostate
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Screening
Sugars
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inhibited: N‐acetylglucosamine (GlcNAc) derivatives with a fluorine atom at the C4 position (2–4) were synthesized, and their ability to inhibit cancer‐cell growth was investigated. The administration of these 4F‐GlcNAc derivatives to cells led to the unnatural sugar nucleotide 1. Furthermore, N‐glycan profiles of cells were determined by using a glycoblotting‐based enrichment analysis, which is suitable for high‐throughput screenings for drug discovery.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201108742