Quantifying Analytes in Paper-Based Microfluidic Devices Without Using External Electronic Readers

A matter of time: Two quantitative assays are presented that require only measurements of time and the ability to see and/or count to quantify the presence of a specific analyte. The strategies rely on specific changes in wetting properties of paper when a hydrophobic detection reagent (compound 1)...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-12, Vol.51 (51), p.12707-12710
Main Authors: Lewis, Gregory G., DiTucci, Matthew J., Phillips, Scott T.
Format: Article
Language:English
Subjects:
Analytical chemistry
analytical methods
Counting
Devices
Electronics
Heterocyclic Compounds, 3-Ring - chemistry
Hydrogen Peroxide - analysis
Hydrophobic and Hydrophilic Interactions
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Microfluidics
Oxidation-Reduction
paper diagnostic
point-of-care assays
Point-of-Care Systems
Readers
sensors
Strategy
Wetting
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Summary:A matter of time: Two quantitative assays are presented that require only measurements of time and the ability to see and/or count to quantify the presence of a specific analyte. The strategies rely on specific changes in wetting properties of paper when a hydrophobic detection reagent (compound 1) reacts with a desired analyte to produce hydrophilic products. This change in wetting properties enables selective and quantitative detection of the analyte.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207239