Intrinsically Copper-64-Labeled Organic Nanoparticles as Radiotracers

PET friendly: Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one‐pot, high‐yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activity ever reported for a 64Cu‐labeled nano...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-12, Vol.51 (52), p.13128-13131
Main Authors: Liu, Tracy W., MacDonald, Thomas D., Shi, Jiyun, Wilson, Brian C., Zheng, Gang
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Contrast Media - chemical synthesis
Contrast Media - chemistry
Copper - chemistry
Copper Radioisotopes - chemistry
Disease Models, Animal
EMISSIONS
fluorescence
Humans
Imaging
Labels
Male
Metal Nanoparticles - chemistry
Mice
Nanoparticles
ORGANIC COMPOUNDS
PARTICLES
porphyrins
Porphyrins - chemistry
Positron emission
Positron-Emission Tomography
prostate cancer
Prostatic Neoplasms - diagnostic imaging
radiochemistry
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Tomography
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Summary:PET friendly: Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one‐pot, high‐yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activity ever reported for a 64Cu‐labeled nanoparticle. These 64Cu‐porphysomes can be accurately and noninvasively tracked in vivo.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206939