DeNovo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex

Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N sub(3)) sub(2)(OH) sub(2)(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolv...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-12, Vol.52 (51), p.13633-13637
Main Authors: Zhao, Yao, Farrer, Nicola J, Li, Huilin, Butler, Jennifer S, McQuitty, Ruth J, Habtemariam, Abraha, Wang, Fuyi, Sadler, Peter J
Format: Article
Language:English
Subjects:
Ammines
Conversion
Dissolution
Excitation
Guanines
Ligands
Platinum
Singlet oxygen
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Summary:Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N sub(3)) sub(2)(OH) sub(2)(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201307505