Backbone FC--HO Hydrogen Bonds in 2'F-Substituted Nucleic Acids

Polarizing C--HO hydrogen bonds: The structure of oligonucleotides containing alternating and contiguous tracts of 2'F-RNA and 2'F-ANA nucleotides reveals that nonconventional FC--HO hydrogen bonds have a strong stabilizing effect on 2'-fluorinated duplexes.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12065-12068
Main Authors: Martin-Pintado, Nerea, Deleavey, Glen F, Portella, Guillem, Campos-Olivas, Ramon, Orozco, Modesto, Damha, Masad J, Gonzalez, Carlos
Format: Article
Language:English
Subjects:
Backbone
Hydrogen bonds
Nucleic acids
Nucleotides
Oligonucleotides
Polarization
Online Access:Get full text
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Description
Summary:Polarizing C--HO hydrogen bonds: The structure of oligonucleotides containing alternating and contiguous tracts of 2'F-RNA and 2'F-ANA nucleotides reveals that nonconventional FC--HO hydrogen bonds have a strong stabilizing effect on 2'-fluorinated duplexes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201305710