Nickel-Catalyzed Sonogashira Reactions of Non-activated Secondary Alkyl Bromides and Iodides

A nicked reaction: The title reaction of terminal alkynes with non‐activated secondary alkyl iodides and bromides was accomplished for the first time. This reaction provides a new and practical approach for the synthesis of substituted alkynes (see scheme; cod=cyclo‐1,5‐octadiene).

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-11, Vol.52 (47), p.12409-12413
Main Authors: Yi, Jun, Lu, Xi, Sun, Yan-Yan, Xiao, Bin, Liu, Lei
Format: Article
Language:English
Subjects:
Alkynes
Alkynes - chemical synthesis
Alkynes - chemistry
Bromides
Bromides - chemistry
Catalysis
Coordination Complexes - chemistry
cross-coupling
Crystallography, X-Ray
halides
Iodides
Iodides - chemistry
Molecular Conformation
Nickel
Nickel - chemistry
Stereoisomerism
Synthesis
synthetic methods
Terminals
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Summary:A nicked reaction: The title reaction of terminal alkynes with non‐activated secondary alkyl iodides and bromides was accomplished for the first time. This reaction provides a new and practical approach for the synthesis of substituted alkynes (see scheme; cod=cyclo‐1,5‐octadiene).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201307069