Use of an Itraconazole/Allopurinol Combination for the Treatment of Visceral Leishmaniasis in a Patient with AIDS

We report the case of a patient with AIDS and visceral leishmaniasis who responded clinically to first-line treatment with a combination of allopurinol and itraconazole. A 32-year-old man who was infected with HIV-1 developed visceral leishmaniasis. Examination of a bone marrow aspirate and a blood...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 1995-11, Vol.21 (5), p.1338-1339
Main Authors: Raffi, François, Merrien, Dominique, Le Pape, Patrice, Reliquet, Véronique
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - drug therapy
AIDS-Related Opportunistic Infections - parasitology
Allopurinol - administration & dosage
Animals
Anti-Infective Agents - administration & dosage
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimetabolites - administration & dosage
Antiparasitic agents
Biological and medical sciences
Blood
Bone marrow
Brief Reports
Humans
Itraconazole - administration & dosage
Leishmania
Leishmania - isolation & purification
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - parasitology
Maintenance chemotherapy
Male
Medical sciences
Pharmacology. Drug treatments
Relapse
Visceral leishmaniasis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the case of a patient with AIDS and visceral leishmaniasis who responded clinically to first-line treatment with a combination of allopurinol and itraconazole. A 32-year-old man who was infected with HIV-1 developed visceral leishmaniasis. Examination of a bone marrow aspirate and a blood smear revealed Leishmania species amastigotes. Culture of a bone marrow specimen yielded Leismania species. Concomitant fungal infection was ruled out by a thorough investigation (blood cultures, stains and cultures of bone marrow). The patient refused to be hospitalized; he was then treated on an outpatient basis with a combination of oral allopurinol (21 mg/[kg times d]) and itraconazole (400 mg once daily). Three months after therapy was begun the patient was free of symptoms, and his liver and spleen were no longer palpable.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/21.5.1338