Bone morphogenetic protein-1: The type 1 procollagen C-proteinase

Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs BMP-1 is not like transforming growth factor- beta (TGF- beta ), but it is the prototype of a family of putative proteases implicated in pattern formation during development in d...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-01, Vol.271 (5247), p.360-362
Main Authors: Kessler, E, Takahara, K, Biniaminov, L, Brusel, M, Greenspan, D S
Format: Article
Language:English
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Summary:Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs BMP-1 is not like transforming growth factor- beta (TGF- beta ), but it is the prototype of a family of putative proteases implicated in pattern formation during development in diverse organisms. Although some members of this group, such as Drosophila tolloid (TLD), are postulated to activate TGF- beta -like proteins, actual substrates are unknown. Procollagen C-proteinase (PCP) cleaves the COOH-propeptides of procollagens I, II, and III to yield the major fibrous components of vertebrate extracellular matrix. Here it is shown that BMP-1 and PCP are identical. This demonstration of enzymatic activity for a BMP-1/TLD-like protein links an enzyme involved in matrix deposition to genes involved in pattern formation.
ISSN:0036-8075