Depression and Risk for Diabetes: A Meta-Analysis

Abstract Objective Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes. Methods We retrieved...

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Bibliographic Details
Published in:Canadian journal of diabetes 2015-08, Vol.39 (4), p.266-272
Main Authors: Yu, Min, MD, Zhang, Xingliang, MD, Lu, Feng, MD, Fang, Le, PhD
Format: Article
Language:English
Subjects:
Case-Control Studies
Cohort Studies
Cross-Sectional Studies
depression
Depression - diagnosis
Depression - epidemiology
Depression - psychology
diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - psychology
diabète
dépression
Endocrinology & Metabolism
facteurs de risque
Humans
meta-analysis
méta-analyse
Other
Risk Factors
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Summary:Abstract Objective Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes. Methods We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test. Results As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25–1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18–1.47). Conclusions Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.
ISSN:1499-2671
2352-3840
DOI:10.1016/j.jcjd.2014.11.006