Serum lipid levels in a group of cocaine dependent subjects in recent abstinence

Chronic cocaine users develop multiple potentially lethal ischemic vascular complications associated with accelerated atherosclerosis. To assess biochemical and lipid profiles among cocaine dependent subjects in recent abstinence. A blood sample to measure blood count, biochemical and lipid profiles...

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Bibliographic Details
Published in:Revista medíca de Chile 2015-06, Vol.143 (6), p.697-706
Main Authors: Massardo, Teresa, Araya, Verónica, Ibáñez, Carlos, Véliz, Jonathan, Fernández, René, Jaimovich, Rodrigo, Pallavicini, Julio, Chandía, Rolando, Pereira, Karla, Pereira, Jaime
Format: Article
Language:Spanish
Subjects:
Adult
Body Mass Index
Cardiovascular Diseases
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cocaine - adverse effects
Cocaine-Related Disorders - blood
Female
Humans
Lipids - blood
Male
Middle Aged
Prospective Studies
Sex Factors
Triglycerides - blood
Young Adult
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Summary:Chronic cocaine users develop multiple potentially lethal ischemic vascular complications associated with accelerated atherosclerosis. To assess biochemical and lipid profiles among cocaine dependent subjects in recent abstinence. A blood sample to measure blood count, biochemical and lipid profiles was obtained from 78 patients aged 19 to 53 years (78% males) who complied with DSM-IV criteria for cocaine dependency. Laboratory results were compared with a group of normal subjects. All cases had positive urinary cocaine, with a mean consumption lapse of 7.6 years. The frequency of smoking was higher in cases. Dependent males had higher body mass index than controls. Compared to controls, dependent females had significantly higher triglyceride (TG) levels and lower HDL cholesterol. Therefore the relation total/HDL cholesterol was higher (p = 0.0365). Dependent males had higher TG levels than their normal counterparts. Dependent subjects consuming cocaine base-paste had higher TG levels. Total proteins, albumin, urea and blood urea nitrogen were lower in dependent subjects. Among males, serum creatinine was lower and blood urea was positively correlated with the daily amount of cocaine use (p = 0.03). After a month of strict abstinence, lipid profile was repeated in 27 patients and remained unchanged. Chronic cocaine use was associated with higher TG in both genders and lower HDL cholesterol in women when compared with a group of healthy counterparts.
ISSN:0717-6163
DOI:10.4067/S0034-98872015000600002