Environmental exposures, breast development and cancer risk: Through the looking glass of breast cancer prevention

•Timing matters during the life course to identify when an exposure influences breast development or cancer risk.•Transdisciplinary research can accelerate knowledge about environmental exposures and mechanisms related to breast development and cancer risk.•Animal–human research discovery of windows...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2015-07, Vol.54, p.6-10
Main Authors: Forman, Michele R., Winn, Deborah M., Collman, Gwen W., Rizzo, Jeanne, Birnbaum, Linda S.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Breast cancer
Breast development
Breast Neoplasms - chemically induced
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - prevention & control
Carcinogens, Environmental - toxicity
Cell Transformation, Neoplastic - chemically induced
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Environment
Environmental Exposure - adverse effects
Female
Humans
Life course
Life Style
Male
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - metabolism
Mammary Glands, Animal - pathology
Mammary Glands, Human - drug effects
Mammary Glands, Human - metabolism
Mammary Glands, Human - pathology
Maternal Exposure - adverse effects
Pregnancy
Prenatal Exposure Delayed Effects
Prevention
Risk Assessment
Risk Factors
Signal Transduction - drug effects
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Description
Summary:•Timing matters during the life course to identify when an exposure influences breast development or cancer risk.•Transdisciplinary research can accelerate knowledge about environmental exposures and mechanisms related to breast development and cancer risk.•Animal–human research discovery of windows of susceptibility, and pathways enhances to derangement of normal breast development and cancer risk.•The Interagency Breast Cancer and Environmental Research Coordinating Committee was tasked to review the science, identify gaps, and evaluate options for dissemination of result. This review summarizes the report entitled: Breast Cancer and the Environment: Prioritizing Prevention, highlights research gaps and the importance of focusing on early life exposures for breast development and breast cancer risk.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2014.10.019