Cytokine-induced sleep: Neurons respond to TNF with production of chemokines and increased expression of Homer1a in vitro

Highlights • The response of neurons to TNF is limited to chemokines acting on microglia and macrophages. • Chemokines produced by TNF treated neurons does not comprise factors acting on resting lymphocytes. • TNF does not repress Homer1a expression in neurons in vitro. • Regulation of Homer1a expre...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-07, Vol.47, p.186-192
Main Authors: Karrer, Maureen, Lopez, Martin Alexander, Meier, Daniel, Mikhail, Cyril, Ogunshola, Omolara O, Müller, Andreas Felix, Strauss, Laura, Tafti, Mehdi, Fontana, Adriano
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Line
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Chemokines - blood
Chemokines - metabolism
Depression
Early Growth Response Protein 2 - genetics
Early Growth Response Protein 2 - metabolism
Homer Scaffolding Proteins
Inflammatory bowel disease
Interleukin-1beta - pharmacology
Mice
Multiple sclerosis
Neuroinflammation
Neurons - drug effects
Neurons - metabolism
Psychiatry
Rheumatoid arthritis
Sickness behavior
Tumor Necrosis Factor-alpha - pharmacology
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Summary:Highlights • The response of neurons to TNF is limited to chemokines acting on microglia and macrophages. • Chemokines produced by TNF treated neurons does not comprise factors acting on resting lymphocytes. • TNF does not repress Homer1a expression in neurons in vitro. • Regulation of Homer1a expression by TNF in neuronal cultures differs from what is seen in vivo.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.11.008