Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

•Anti-androgen (AA) activity was detected in extracts of coastal sediments.•AA activity was 0.2–224.3±38.4μg flutamide equivalents/g dry weight of sediment.•AA activity was present in clams due to uptake of a series of 4 or 5 ring PAHs. This study analysed the levels of androgen receptor antagonist...

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Bibliographic Details
Published in:Marine pollution bulletin 2015-06, Vol.95 (2), p.590-597
Main Authors: Alvarez-Muñoz, Diana, Indiveri, Paolo, Rostkowski, Pawel, Horwood, Julia, Greer, Emily, Minier, Christophe, Pope, Nick, Langston, William J., Hill, Elizabeth M.
Format: Article
Language:English
Subjects:
Androgen Antagonists - analysis
Androgen Antagonists - metabolism
Androgen Antagonists - toxicity
Animals
Anti-androgen
Aquatic Organisms
AR-CALUX
Bivalvia - physiology
Brackish
Clam
Effect-directed analysis
Endocrine disruption
Environmental Monitoring
Estuaries
Female
France
Geologic Sediments - chemistry
Male
Marine
Polycyclic Aromatic Hydrocarbons - analysis
Scrobicularia plana
Sediment
United Kingdom
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - metabolism
Water Pollutants, Chemical - toxicity
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Summary:•Anti-androgen (AA) activity was detected in extracts of coastal sediments.•AA activity was 0.2–224.3±38.4μg flutamide equivalents/g dry weight of sediment.•AA activity was present in clams due to uptake of a series of 4 or 5 ring PAHs. This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between
ISSN:0025-326X
1879-3363
DOI:10.1016/j.marpolbul.2014.11.014