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Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds
•Anti-androgen (AA) activity was detected in extracts of coastal sediments.•AA activity was 0.2–224.3±38.4μg flutamide equivalents/g dry weight of sediment.•AA activity was present in clams due to uptake of a series of 4 or 5 ring PAHs. This study analysed the levels of androgen receptor antagonist...
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| Published in: | Marine pollution bulletin 2015-06, Vol.95 (2), p.590-597 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-a497t-f37607fd732c6e4f06d8d11ca5c30dc3c7a05ceeff279244aa8796119e84c12f3 |
| container_end_page | 597 |
| container_issue | 2 |
| container_start_page | 590 |
| container_title | Marine pollution bulletin |
| container_volume | 95 |
| creator | Alvarez-Muñoz, Diana Indiveri, Paolo Rostkowski, Pawel Horwood, Julia Greer, Emily Minier, Christophe Pope, Nick Langston, William J. Hill, Elizabeth M. |
| description | •Anti-androgen (AA) activity was detected in extracts of coastal sediments.•AA activity was 0.2–224.3±38.4μg flutamide equivalents/g dry weight of sediment.•AA activity was present in clams due to uptake of a series of 4 or 5 ring PAHs.
This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between |
| doi_str_mv | 10.1016/j.marpolbul.2014.11.014 |
| format | article |
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This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.</description><identifier>ISSN: 0025-326X</identifier><identifier>EISSN: 1879-3363</identifier><identifier>DOI: 10.1016/j.marpolbul.2014.11.014</identifier><identifier>PMID: 25496695</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Androgen Antagonists - analysis ; Androgen Antagonists - metabolism ; Androgen Antagonists - toxicity ; Animals ; Anti-androgen ; Aquatic Organisms ; AR-CALUX ; Bivalvia - physiology ; Brackish ; Clam ; Effect-directed analysis ; Endocrine disruption ; Environmental Monitoring ; Estuaries ; Female ; France ; Geologic Sediments - chemistry ; Male ; Marine ; Polycyclic Aromatic Hydrocarbons - analysis ; Scrobicularia plana ; Sediment ; United Kingdom ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - metabolism ; Water Pollutants, Chemical - toxicity</subject><ispartof>Marine pollution bulletin, 2015-06, Vol.95 (2), p.590-597</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a497t-f37607fd732c6e4f06d8d11ca5c30dc3c7a05ceeff279244aa8796119e84c12f3</citedby><cites>FETCH-LOGICAL-a497t-f37607fd732c6e4f06d8d11ca5c30dc3c7a05ceeff279244aa8796119e84c12f3</cites><orcidid>0000-0003-4116-1233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25496695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alvarez-Muñoz, Diana</creatorcontrib><creatorcontrib>Indiveri, Paolo</creatorcontrib><creatorcontrib>Rostkowski, Pawel</creatorcontrib><creatorcontrib>Horwood, Julia</creatorcontrib><creatorcontrib>Greer, Emily</creatorcontrib><creatorcontrib>Minier, Christophe</creatorcontrib><creatorcontrib>Pope, Nick</creatorcontrib><creatorcontrib>Langston, William J.</creatorcontrib><creatorcontrib>Hill, Elizabeth M.</creatorcontrib><title>Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds</title><title>Marine pollution bulletin</title><addtitle>Mar Pollut Bull</addtitle><description>•Anti-androgen (AA) activity was detected in extracts of coastal sediments.•AA activity was 0.2–224.3±38.4μg flutamide equivalents/g dry weight of sediment.•AA activity was present in clams due to uptake of a series of 4 or 5 ring PAHs.
This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.</description><subject>Androgen Antagonists - analysis</subject><subject>Androgen Antagonists - metabolism</subject><subject>Androgen Antagonists - toxicity</subject><subject>Animals</subject><subject>Anti-androgen</subject><subject>Aquatic Organisms</subject><subject>AR-CALUX</subject><subject>Bivalvia - physiology</subject><subject>Brackish</subject><subject>Clam</subject><subject>Effect-directed analysis</subject><subject>Endocrine disruption</subject><subject>Environmental Monitoring</subject><subject>Estuaries</subject><subject>Female</subject><subject>France</subject><subject>Geologic Sediments - chemistry</subject><subject>Male</subject><subject>Marine</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Scrobicularia plana</subject><subject>Sediment</subject><subject>United Kingdom</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - metabolism</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0025-326X</issn><issn>1879-3363</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkE9v1DAQxS0EokvhK0COXBL8L_bmWK0oIFXiUgQ3a2qPu14ldrAdEN8eV1t65fRGozfvaX6EvGN0YJSpD6dhgbym-W6bB06ZHBgbmjwjO7bXUy-EEs_JjlI-9oKrHxfkVSknSqnmmr0kF3yUk1LTuCP334PDsmYE19kUKywhQg0pdsm3BZQKc1fQhQVjLV2IXT1id5shlgWibfPhCDHi3P0O9dhBrKGH6HK6xxhsS1jWtEVXXpMXHuaCbx71kny7_nh7-NzffP305XB104OcdO290Ipq77TgVqH0VLm9Y8zCaAV1VlgNdLSI3nM9cSkB2ruKsQn30jLuxSV5f85dc_q5YalmCcXiPEPEtBXDdMM0Ualks-qz1eZUSkZv1hwa1j-GUfNA2ZzME2XzQNkwZpq0y7ePJdvdgu7p7h_WZrg6G7C9-itgNsUGjLZxzGircSn8t-QvYvKU0g</recordid><startdate>20150630</startdate><enddate>20150630</enddate><creator>Alvarez-Muñoz, Diana</creator><creator>Indiveri, Paolo</creator><creator>Rostkowski, Pawel</creator><creator>Horwood, Julia</creator><creator>Greer, Emily</creator><creator>Minier, Christophe</creator><creator>Pope, Nick</creator><creator>Langston, William J.</creator><creator>Hill, Elizabeth M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TG</scope><scope>7TN</scope><scope>7TV</scope><scope>7UA</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H97</scope><scope>H99</scope><scope>KL.</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0003-4116-1233</orcidid></search><sort><creationdate>20150630</creationdate><title>Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds</title><author>Alvarez-Muñoz, Diana ; Indiveri, Paolo ; Rostkowski, Pawel ; Horwood, Julia ; Greer, Emily ; Minier, Christophe ; Pope, Nick ; Langston, William J. ; Hill, Elizabeth M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a497t-f37607fd732c6e4f06d8d11ca5c30dc3c7a05ceeff279244aa8796119e84c12f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Androgen Antagonists - analysis</topic><topic>Androgen Antagonists - metabolism</topic><topic>Androgen Antagonists - toxicity</topic><topic>Animals</topic><topic>Anti-androgen</topic><topic>Aquatic Organisms</topic><topic>AR-CALUX</topic><topic>Bivalvia - physiology</topic><topic>Brackish</topic><topic>Clam</topic><topic>Effect-directed analysis</topic><topic>Endocrine disruption</topic><topic>Environmental Monitoring</topic><topic>Estuaries</topic><topic>Female</topic><topic>France</topic><topic>Geologic Sediments - chemistry</topic><topic>Male</topic><topic>Marine</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Scrobicularia plana</topic><topic>Sediment</topic><topic>United Kingdom</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - metabolism</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alvarez-Muñoz, Diana</creatorcontrib><creatorcontrib>Indiveri, Paolo</creatorcontrib><creatorcontrib>Rostkowski, Pawel</creatorcontrib><creatorcontrib>Horwood, Julia</creatorcontrib><creatorcontrib>Greer, Emily</creatorcontrib><creatorcontrib>Minier, Christophe</creatorcontrib><creatorcontrib>Pope, Nick</creatorcontrib><creatorcontrib>Langston, William J.</creatorcontrib><creatorcontrib>Hill, Elizabeth M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Marine pollution bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alvarez-Muñoz, Diana</au><au>Indiveri, Paolo</au><au>Rostkowski, Pawel</au><au>Horwood, Julia</au><au>Greer, Emily</au><au>Minier, Christophe</au><au>Pope, Nick</au><au>Langston, William J.</au><au>Hill, Elizabeth M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds</atitle><jtitle>Marine pollution bulletin</jtitle><addtitle>Mar Pollut Bull</addtitle><date>2015-06-30</date><risdate>2015</risdate><volume>95</volume><issue>2</issue><spage>590</spage><epage>597</epage><pages>590-597</pages><issn>0025-326X</issn><eissn>1879-3363</eissn><abstract>•Anti-androgen (AA) activity was detected in extracts of coastal sediments.•AA activity was 0.2–224.3±38.4μg flutamide equivalents/g dry weight of sediment.•AA activity was present in clams due to uptake of a series of 4 or 5 ring PAHs.
This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25496695</pmid><doi>10.1016/j.marpolbul.2014.11.014</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4116-1233</orcidid></addata></record> |
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| ispartof | Marine pollution bulletin, 2015-06, Vol.95 (2), p.590-597 |
| issn | 0025-326X 1879-3363 |
| language | eng |
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| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Androgen Antagonists - analysis Androgen Antagonists - metabolism Androgen Antagonists - toxicity Animals Anti-androgen Aquatic Organisms AR-CALUX Bivalvia - physiology Brackish Clam Effect-directed analysis Endocrine disruption Environmental Monitoring Estuaries Female France Geologic Sediments - chemistry Male Marine Polycyclic Aromatic Hydrocarbons - analysis Scrobicularia plana Sediment United Kingdom Water Pollutants, Chemical - analysis Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity |
| title | Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds |
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