Chlorophyllin-M: A new substance for photodynamic therapy in the retina and choroid

Background and Objective Chlorophyllin‐M is a new chlorophyll‐based derivative photosensitive compound developed by our research group with easy laboratorial synthesis and ideal properties for photodynamic therapy (PDT). It is intended for clinical treatments with simple and low cost techniques and...

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Published in:Lasers in surgery and medicine 2015-07, Vol.47 (5), p.421-425
Main Authors: Salomao, Gustavo Henrique Araujo, Fernandes, Adjaci Uchoa, Baptista, Mauricio S., Tardivo, João Paulo, Christofolini, Denise Maria, Correa, João Antonio
Format: Article
Language:English
Subjects:
Animals
Antimutagenic Agents - pharmacology
Chlorophyllides - pharmacology
Choroid - drug effects
Choroid - radiation effects
Fluorescein Angiography
LASER
neovascular
ocular
Photochemotherapy
Photosensitizing Agents - pharmacology
Rabbits
Retina - drug effects
Retina - radiation effects
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Summary:Background and Objective Chlorophyllin‐M is a new chlorophyll‐based derivative photosensitive compound developed by our research group with easy laboratorial synthesis and ideal properties for photodynamic therapy (PDT). It is intended for clinical treatments with simple and low cost techniques and reagents. The objective of this study is to evaluate if intravenous chlorophyllin‐M is able to deliver a photosensitizer to rabbit retina and rabbit choroid and promote PDT after ocular irradiation with a 660 nm LASER. Methods This is a pre‐clinical study. Ten eyes of five pigmented Californian rabbits were included in the study. The right eyes served as the treatment group, and the left eyes served as the control group. All eyes had been ophthalmologically evaluated and were considered normal. Results Ophthalmic exam with anterior biomicroscopy, dilated fundus examination, and fluorescein angiography after the LASER procedure revealed normal anterior segment, retinal and choroid vessels occlusion, lumen narrowing, and capillary non‐perfusion in the treated areas, indicating that PDT was successful in the treatment eyes group. Conclusion The results of this pre‐clinical study encourage future studies with this new compound. Chlorophyllin‐M may become a new cost‐effective agent in the retinal therapeutic arsenal. Lasers Surg. Med. 47:421–425, 2015. © 2015 Wiley Periodicals, Inc.
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.22362