Preclinical immunogenicity study of trivalent meningococcal AWX-OMV vaccines for the African meningitis belt

Highlights • Vaccines for preventing serogroup AWX meningococcal disease needed in Africa. • An outer membrane vesicle (OMV) vaccine from serogroup AWX meningocci developed. • AWX-OMV vaccine shown to induce bactericidal and opsonic antibodies in mice. • Combination of AW-OMV with X polysaccharide a...

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Bibliographic Details
Published in:Vaccine 2014-11, Vol.32 (49), p.6631-6638
Main Authors: Tunheim, G, Næss, L.M, Acevedo, R, Fjeldheim, Å.K, Bolstad, K, García, L, Cardoso, D, Aase, A, Zayas, C, González, H, Rosenqvist, E, Norheim, G
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Africa
African meningitis belt
Allergy and Immunology
Alum Compounds - administration & dosage
Animals
Antibodies, Bacterial - blood
Antigens
Applied microbiology
Bacteriology
Biological and medical sciences
Blood Bactericidal Activity
Cell-Derived Microparticles - immunology
Drug Evaluation, Preclinical
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Immunization
Immunoblotting
Immunogenicity
Licenses
Meningitis
Meningitis, Meningococcal - epidemiology
Meningitis, Meningococcal - microbiology
Meningitis, Meningococcal - prevention & control
Meningococcal vaccine
Meningococcal Vaccines - immunology
Meningococcal Vaccines - isolation & purification
Mice
Microbiology
Miscellaneous
Neisseria meningitidis
Neisseria meningitidis - immunology
Neisseria meningitidis - isolation & purification
OMV
Opsonin Proteins - blood
Phagocytosis
Polysaccharides, Bacterial - immunology
Proteins
Serogroup
Serogroup X
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Combined - immunology
Vaccines, Combined - isolation & purification
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Summary:Highlights • Vaccines for preventing serogroup AWX meningococcal disease needed in Africa. • An outer membrane vesicle (OMV) vaccine from serogroup AWX meningocci developed. • AWX-OMV vaccine shown to induce bactericidal and opsonic antibodies in mice. • Combination of AW-OMV with X polysaccharide also induced bactericidal antibodies. • Vaccine based on AWX-OMV or AW-OMV + X polysaccharide may prevent majority of cases.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.09.063