Electrophysiological association of spontaneous yawning and swallowing

• Published in: Experimental brain research 2015-07, Vol.233 (7), p.2073-2080
• Main Authors: Ertekin, Cumhur, Bulbul, Nazlı Gamze, Uludag, Irem Fatma, Tiftikcioglu, Bedile Irem, Arici, Sehnaz, Gurgor, Nevin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomedical and Life Sciences; Biomedicine; Brain research; Brain Stem - physiology; Deglutition - physiology; Dysphagia; Electromyography; Electrophysiological Phenomena - physiology; Female; Health aspects; Humans; Hypotheses; Larynx; Male; Middle Aged; Neurology; Neurophysiology; Neurosciences; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Physiological aspects; Physiology; Research Article; Sleep; Stroke - pathology; Stroke - physiopathology; Yawning - physiology
• ISSN: 0014-4819; 1432-1106
• DOI: 10.1007/s00221-015-4278-9

Yawning and swallowing are fundamental physiological processes that are present from fetal stages throughout life and that involve sequential motor activities in the oropharyngo-larynx making it likely that they may share neuroanatomical pathways. We postulate that yawning and swallowing are controlled by a distributed network of brainstem regions including the central pattern generator of swallowing, and therefore spontaneous swallowing is frequently associated with spontaneous yawning. In this study, we sought to test this hypothesis by evaluating the elementary features of yawning in the facial, masseter and submental muscles, together with laryngeal movement sensor and respiratory recordings for spontaneous swallowing. We investigated 15 healthy, normal control subjects, 10 patients with Parkinson’s disease (PD) and 10 patients with brainstem stroke (BSS). Apart from four subjects with PD and two with BSS, who had dysphagia, none of the other study subjects were dysphagic by published criteria. Twenty-five subjects (10 control, 10 BSS, 5 PD) were evaluated by 1-h polygraphic recording, and 10 (5 control, 5 PD) underwent whole-night sleep recordings. One hundred thirty-two yawns were collected, 113 of which were associated with spontaneous swallows, a clear excess of what would be considered as coincidence. The yawns related with swallows could be classified into the following three categories. The characteristics or the duration of swallows and yawns were similar between controls and disease subjects, with the exception of increased duration of yawning in subjects with BSS. Our findings support the presence of common neuroanatomico-physiological pathways for spontaneous swallows and yawning.