Inducible stable DNA replication of Escherichia coli tolerates unexcised pyrimidine dimers in an uvr-dependent manner

Damage-inducible DNA replication (iSDR) was followed in UV-irradiated E. coli uvr + and uvrB5. Owing to the inhibition of dimer excision in the former (caused by the metabolic treatment), both contained similar amounts of unexcised dimers. Since iSDR took place in uvr + but not in uvrB5 cells, it is...

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Bibliographic Details
Published in:Mutation research. Mutation research letters 1995, Vol.346 (1), p.9-13
Main Authors: SEDLIAKOVA, M, SLEZARIKOVA, V, MASEK, F, PIRSEL, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Escherichia coli
Fundamental and applied biological sciences. Psychology
Inducible stable DNA replication
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Thymine starvation
UV irradiation
Uvr system
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Summary:Damage-inducible DNA replication (iSDR) was followed in UV-irradiated E. coli uvr + and uvrB5. Owing to the inhibition of dimer excision in the former (caused by the metabolic treatment), both contained similar amounts of unexcised dimers. Since iSDR took place in uvr + but not in uvrB5 cells, it is concluded that the uvr system can tolerate unexcised dimers through the recombinogenic iSDR.
ISSN:0165-7992
DOI:10.1016/0165-7992(95)90062-4