Working groups I and II: Microbial colonisation of the body

Genetically engineered microorganisms (GEMs) may be divided into targeted and non-targeted groups. Targeted groups are specifically designed for human application, whereas non-targeted groups are applicable to a particular ecosystem where humans are not directly involved. The suggestions here have b...

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Main Authors: Benbadis, L, Cohen, P S, Contrepois, M, Conway, P, Duval-Iflah, Y, Gasson, MJ, Blix Gundersen, W, Hentges, D J, Jacobsen, B L, Klemm, P, Krivan, H, Krogfeldt, KA, Lintermanns, P, Moller Nielsen, E, Norin, E
Format: Conference Proceeding
Language:English
Online Access:Get full text
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Summary:Genetically engineered microorganisms (GEMs) may be divided into targeted and non-targeted groups. Targeted groups are specifically designed for human application, whereas non-targeted groups are applicable to a particular ecosystem where humans are not directly involved. The suggestions here have been discussed in relation to GEM's targeted for the gastrointestinal tract: 1. Colonisation is the detection of a microorganism for a relevant period of time at a constant level. 2. Survival is the detection of a microorganism for a limited period of time where the growth rate is lower than the rate of elimination. 3. Detection is limited by the state of the art of available methodology which includes selective plating, microscopy, immunoassays, selective isolation using receptors and/or antibodies, and gene technology such as PCR, rRNA, and other nucleic acid probes.
ISSN:0891-060X