Tactoid body features in a Schwann cell hamartoma of colonic mucosa

Background. Mesenchymal colorectal polyps are uncommon lesions, particularly those of neurogenic origin. We describe a mucosal Schwann cell hamartoma of the colon with tactoid features, so far reported in peripheral nerve sheath tumours, and address its differential diagnosis and clinical implicatio...

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Bibliographic Details
Published in:International journal of surgical pathology 2014-08, Vol.22 (5), p.438-441
Main Authors: de Beça, Francisco Ferro, Lopes, Joanne, Maçoas, Fernanda, Carneiro, Fátima, Lopes, José Manuel
Format: Article
Language:English
Subjects:
Aged
Colon - metabolism
Colon - pathology
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Colonic Polyps - metabolism
Colonic Polyps - pathology
Diagnosis, Differential
Hamartoma - metabolism
Hamartoma - pathology
Humans
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Male
Schwann Cells - metabolism
Schwann Cells - pathology
Vimentin - metabolism
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Summary:Background. Mesenchymal colorectal polyps are uncommon lesions, particularly those of neurogenic origin. We describe a mucosal Schwann cell hamartoma of the colon with tactoid features, so far reported in peripheral nerve sheath tumours, and address its differential diagnosis and clinical implications. Case presentation. A 72-year-old man underwent screening colonoscopy that presented a 5-mm polyp on distal sigmoid. Histologically, it displayed a lesion in the lamina propria comprising oval structures with tactoid features and bland spindle cells, entrapping adjacent crypts. No ganglion cells were seen. Spindle cells expressed only S-100 protein and vimentin. Discussion. Mucosal Schwann cell hamartoma was recently recognized as distinct from common (submucosal) colorectal Schwannomas and so far not associated to inherited syndromes. Thus, it should be considered in the differential diagnosis of look-alike lesions (eg, ganglioneuroma, neuroma, and neurofibroma) that may occur in the setting of inherited syndromes such as Cowden syndrome, multiple endocrine neoplasia-2B, and type 1 neurofibromatosis.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896913501384