Effects of lipid composition on the properties of doxorubicin-loaded liposomes

The liposomal lipid composition of doxorubicin-loaded liposome likely will influence its pharmacological activity. Results & methodology: We prepared 18 formulations of doxorubicin-loaded liposomes in which the lipid composition was varied. It was indicated that the intracellular uptake of doxor...

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Bibliographic Details
Published in:Therapeutic delivery 2015-07, Vol.6 (7), p.785-794
Main Authors: Sakai-Kato, Kumiko, Nanjo, Kunie, Kawanishi, Toru, Okuda, Haruhiro, Goda, Yukihiro
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - metabolism
Antibiotics, Antineoplastic - pharmacology
Cell Survival - drug effects
Chemistry, Pharmaceutical
Doxorubicin - administration & dosage
Doxorubicin - analogs & derivatives
Doxorubicin - chemistry
Doxorubicin - metabolism
Doxorubicin - pharmacology
HeLa Cells
Humans
Kinetics
Lipids - chemistry
Liposomes
Neoplasms - metabolism
Neoplasms - pathology
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - chemistry
Polyethylene Glycols - metabolism
Polyethylene Glycols - pharmacology
Solubility
Technology, Pharmaceutical - methods
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Summary:The liposomal lipid composition of doxorubicin-loaded liposome likely will influence its pharmacological activity. Results & methodology: We prepared 18 formulations of doxorubicin-loaded liposomes in which the lipid composition was varied. It was indicated that the intracellular uptake of doxorubicin is the primary property of doxorubicin-loaded liposome that affects its cytotoxicity in vitro. Furthermore, the release rate of doxorubicin from liposome and the biological activity of the lipid itself also affected the cytotoxicity. These findings provide an insight into how lipid composition influences the cytotoxicity of the doxorubicin-loaded liposomes. Our results provide valuable information that should help to enhance the therapeutic efficacy of liposomal anticancer drug products by optimizing their formulations.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde.15.29