Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

Summary This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the p...

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Bibliographic Details
Published in:British journal of haematology 2015-08, Vol.170 (4), p.559-563
Main Authors: Civaschi, Elisa, Klersy, Catherine, Melazzini, Federica, Pujol‐Moix, Nuria, Santoro, Cristina, Cattaneo, Marco, Lavenu‐Bombled, Cécile, Bury, Loredana, Minuz, Pietro, Nurden, Paquita, Cid, Ana R., Cuker, Adam, Latger‐Cannard, Véronique, Favier, Remi, Nichele, Ilaria, Noris, Patrizia
Format: Article
Language:English
Subjects:
Adolescent
Adult
bleeding diathesis
bleeding risk
Blood Platelet Disorders - therapy
Female
Hemorrhage - prevention & control
Humans
inherited platelet disorders
Middle Aged
perinatal haemostasis
Platelet Transfusion
Pregnancy
Pregnancy Complications, Hematologic - therapy
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Summary:Summary This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky‐Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery‐related bleeding risk.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.13458