Mitochondrial dynamics: Orchestrating the journey to advanced age

Abstract Aging is a degenerative process that unfortunately is an inevitable part of life and risk factor for cardiovascular disease including heart failure. Among the several theories purported to explain the effects of age on cardiac dysfunction, the mitochondrion has emerged a central regulator o...

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Published in:Journal of molecular and cellular cardiology 2015-06, Vol.83, p.37-43
Main Authors: Biala, Agnieszka K, Dhingra, Rimpy, Kirshenbaum, Lorrie A
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Aging - pathology
Animals
Caloric Restriction
Cardiovascular
Cell Death
Gene Expression Regulation
Heart Failure - genetics
Heart Failure - metabolism
Heart Failure - pathology
Humans
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial dynamics
Mitochondrial Dynamics - genetics
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Myocardium - metabolism
Myocardium - pathology
Oxidative Stress
ROS
Signal Transduction
Sirtuins - genetics
Sirtuins - metabolism
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Summary:Abstract Aging is a degenerative process that unfortunately is an inevitable part of life and risk factor for cardiovascular disease including heart failure. Among the several theories purported to explain the effects of age on cardiac dysfunction, the mitochondrion has emerged a central regulator of this process. Hence, it is not surprising that abnormalities in mitochondrial quality control including biogenesis and turnover have such detrimental effects on cardiac function. In fact mitochondria serve as a conduit for biological signals for apoptosis, necrosis and autophagy respectively. The removal of damaged mitochondria by autophagy/mitophagy is essential for mitochondrial quality control and cardiac homeostasis. Defects in mitochondrial dynamism fission/fusion events have been linked to cardiac senescence and heart failure. In this review we discuss the impact of aging on mitochondrial dynamics and senescence on cardiovascular health. This article is part of a Special Issue entitled: CV Aging.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2015.04.015