Vitamin B2 Sensitizes Cancer Cells to Vitamin-C-Induced Cell Death via Modulation of Akt and Bad Phosphorylation

Vitamin C is an essential dietary nutrient that has a variety of biological functions. Recent studies have provided promising evidence for its additional health benefits, including anticancer activity. Vitamin B2, another essential dietary nutrient, often coexists with vitamin C in some fruits, vege...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2015-08, Vol.63 (30), p.6741-6750
Main Authors: Chen, Ni, Yin, Shutao, Song, Xinhua, Fan, Lihong, Hu, Hongbo
Format: Article
Language:English
Subjects:
antineoplastic activity
Apoptosis - drug effects
ascorbic acid
Ascorbic Acid - pharmacology
bcl-Associated Death Protein - genetics
bcl-Associated Death Protein - metabolism
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - physiopathology
cell death
Cell Line, Tumor
chemoprevention
dietary supplements
Drug Synergism
drug therapy
Female
fruits
Humans
neoplasm cells
neoplasms
phosphorylation
Phosphorylation - drug effects
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
riboflavin
Riboflavin - pharmacology
vegetables
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Summary:Vitamin C is an essential dietary nutrient that has a variety of biological functions. Recent studies have provided promising evidence for its additional health benefits, including anticancer activity. Vitamin B2, another essential dietary nutrient, often coexists with vitamin C in some fruits, vegetables, or dietary supplements. The objective of the present study is to determine whether the combination of vitamin C and B2 can achieve a synergistic anticancer activity. MDA-MB-231, MCF-7, and A549 cells were employed to evaluate the combinatory effects of vitamin C and B2. We found that the combination of vitamin C and B2 resulted in a synergistic cell death induction in all cell lines tested. Further mechanistic investigations revealed that vitamin B2 sensitized cancer cells to vitamin C through inhibition of Akt and Bad phosphorylation. Our findings identified vitamin B2 as a promising sensitizer for improving the efficacy of vitamin-C-based cancer chemoprevention and chemotherapy.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.5b01909