Targeting endoplasmic reticulum stress in insulin resistance

Highlights • ER stress is implicated in the development of IR and progression to T2DM. • Unresolved ER stress has been linked to inflammation, lipid synthesis, insulin biosynthesis and β cell apoptosis. • Understanding the mechanisms that link ER stress and IR may provide new pharmacological targets...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2015-08, Vol.26 (8), p.438-448
Main Authors: Salvadó, Laia, Palomer, Xavier, Barroso, Emma, Vázquez-Carrera, Manuel
Format: Article
Language:English
Subjects:
Animals
apoptosis
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - etiology
Endocrinology & Metabolism
endoplasmic reticulum stress
Endoplasmic Reticulum Stress - drug effects
Endoplasmic Reticulum Stress - physiology
Humans
inflammation
insulin resistance
Insulin Resistance - physiology
Signal Transduction - physiology
type 2 diabetes mellitus
unfolded protein response
Unfolded Protein Response - physiology
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Description
Summary:Highlights • ER stress is implicated in the development of IR and progression to T2DM. • Unresolved ER stress has been linked to inflammation, lipid synthesis, insulin biosynthesis and β cell apoptosis. • Understanding the mechanisms that link ER stress and IR may provide new pharmacological targets. • Some drugs currently used for the treatment of T2DM modulate ER stress.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2015.05.007