Cardiac contraction-induced GLUT4 translocation requires dual signaling input

Highlights • AMPK and PKD1 are each required for contraction-stimulated glucose import. • Simultaneous activation of two signaling pathways creates a dual signaling input. • The necessity for dual signaling input refines subsequent metabolic responses.

Saved in:
Bibliographic Details
Published in:Trends in endocrinology and metabolism 2015-08, Vol.26 (8), p.404-410
Main Authors: Luiken, Joost J.F.P, Glatz, Jan F.C, Neumann, Dietbert
Format: Article
Language:English
Subjects:
AMP-Activated Protein Kinases - metabolism
Animals
cardiac contraction
diabetes
Endocrinology & Metabolism
Glucose Transporter Type 4 - metabolism
glucose uptake
heart
Humans
Myocardium - metabolism
Protein Kinase C - metabolism
Signal Transduction - physiology
signaling pathway
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • AMPK and PKD1 are each required for contraction-stimulated glucose import. • Simultaneous activation of two signaling pathways creates a dual signaling input. • The necessity for dual signaling input refines subsequent metabolic responses.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2015.06.002