Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer

Highlights • Depression is a comorbidity in about 30% of patients with cancer. • The study identifies a possible pathophysiological link between cancer and depression. • Phenylalanine/tyrosine ratio was associated with “breast cancer” and “depression”. • Kynurenine/tryptophan ratio was associated wi...

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Published in:Psychoneuroendocrinology 2015-10, Vol.60, p.28-38
Main Authors: Hüfner, K, Oberguggenberger, A, Kohl, C, Geisler, S, Gamper, E, Meraner, V, Egeter, J, Hubalek, M, Beer, B, Fuchs, D, Sperner-Unterweger, B
Format: Article
Language:English
Subjects:
Adult
Aged
Amino Acids - metabolism
Anxiety Disorders - metabolism
Anxiety Disorders - psychology
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - psychology
Catecholamines - metabolism
Depression
Depressive Disorder - psychology
Endocrinology & Metabolism
Female
Health Status
Humans
Kynurenine
Mental Health
Metabolic Networks and Pathways
Middle Aged
Neurotransmitter Agents - metabolism
Phenylalanine
Psychiatric Status Rating Scales
Psychiatry
Serotonin - metabolism
Socioeconomic Factors
State anxiety
Tryptophan
Tyrosine
Young Adult
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Summary:Highlights • Depression is a comorbidity in about 30% of patients with cancer. • The study identifies a possible pathophysiological link between cancer and depression. • Phenylalanine/tyrosine ratio was associated with “breast cancer” and “depression”. • Kynurenine/tryptophan ratio was associated with “breast cancer” and “state anxiety”. • The present results could be the basis for future treatment studies.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.06.001