The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

Highlights • Microgliosis relates to α-synuclein deposition in the brain. • α-Synuclein can activate microglia through TLR. • α-Synuclein induces TNFa and IL1b upregulation. • Microglia are the most efficient cells to clear extracellular α-synuclein.

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Bibliographic Details
Published in:Neuroscience 2015-08, Vol.302, p.47-58
Main Authors: Sanchez-Guajardo, V, Tentillier, N, Romero-Ramos, M
Format: Article
Language:English
Subjects:
alpha-synuclein
alpha-Synuclein - metabolism
Animals
Brain - pathology
Gene Expression Regulation
Humans
Interleukin-1beta - metabolism
microglia
Microglia - metabolism
neuroinflammation
Neurology
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson’s disease
TLR
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:Highlights • Microgliosis relates to α-synuclein deposition in the brain. • α-Synuclein can activate microglia through TLR. • α-Synuclein induces TNFa and IL1b upregulation. • Microglia are the most efficient cells to clear extracellular α-synuclein.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.02.008