Silver-catalyzed cascade reaction of tosylmethyl isocyanide (TosMIC) with propargylic alcohols to (E)-vinyl sulfones: dual roles of TosMIC

An unprecedented silver-catalyzed cascade reaction of tosylmethyl isocyanide (TosMIC) with propargylic alcohols for the efficient synthesis of (E)-vinyl sulfones has been developed where TosMIC plays a dual role as both the reactant in the allenylation of propargylic alcohols and the sulfonyl source...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-08, Vol.13 (32), p.8723-8728
Main Authors: Bounar, Haniya, Liu, Zhenhua, Zhang, Lin, Guan, Xiaoxue, Yang, Zonglian, Liao, Peiqiu, Bi, Xihe, Li, Xingqi
Format: Article
Language:English
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Summary:An unprecedented silver-catalyzed cascade reaction of tosylmethyl isocyanide (TosMIC) with propargylic alcohols for the efficient synthesis of (E)-vinyl sulfones has been developed where TosMIC plays a dual role as both the reactant in the allenylation of propargylic alcohols and the sulfonyl source.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01129a