New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and 0139 Vibrio cholerae

Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and O139 V...

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Bibliographic Details
Published in:Infection and immunity 1996-01, Vol.64 (6), p.2362-2364
Main Authors: Silva, TMJ, Schleupner, MA, Tacket, C O, Steiner, T S, Kaper, J B, Edelman, R, Guerrant, R L
Format: Article
Language:English
Subjects:
Vibrio cholerae
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Summary:Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and O139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent O139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.
ISSN:0019-9567