Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients

Abstract Objective The aim of this study was to investigate the effects of ginger supplementation on serum glucose, advanced glycation end products, oxidative stress, and systemic and vascular inflammatory markers in patients on peritoneal dialysis (PD). Methods In this randomized, double-blind, pla...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-05, Vol.31 (5), p.703-707
Main Authors: Imani, Hossein, Ph.D, Tabibi, Hadi, Ph.D, Najafi, Iraj, M.D, Atabak, Shahnaz, M.D, Hedayati, Mehdi, Ph.D, Rahmani, Leila, M.Sc
Format: Article
Language:English
Subjects:
Adhesion
Adult
Advanced glycation end products
Aged
Arginine - analogs & derivatives
Arginine - blood
Blood Glucose - drug effects
C-Reactive Protein - analysis
Cardiovascular diseases
Cell adhesion & migration
Compliance
Diabetes
Dialysis
Dietary Supplements
Double-Blind Method
E-Selectin - blood
Female
Gastroenterology and Hepatology
Ginger
Glucose
Glycation End Products, Advanced - blood
Humans
Inflammation
Inflammation - blood
Inflammation - diet therapy
Intercellular Adhesion Molecule-1 - blood
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - diet therapy
Kidney Failure, Chronic - therapy
Lysine - analogs & derivatives
Lysine - blood
Male
Malondialdehyde - blood
Middle Aged
Mortality
Oxidative stress
Patients
Peritoneal dialysis
Peritoneal Dialysis - methods
Proteins
Risk factors
Statistical analysis
Treatment Outcome
Urine
Vascular Cell Adhesion Molecule-1 - blood
Zingiber officinale - chemistry
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Summary:Abstract Objective The aim of this study was to investigate the effects of ginger supplementation on serum glucose, advanced glycation end products, oxidative stress, and systemic and vascular inflammatory markers in patients on peritoneal dialysis (PD). Methods In this randomized, double-blind, placebo-controlled trial, 36 patients on PD were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 1000 mg/d ginger for 10 wk, whereas the placebo group received corresponding placebos. At baseline and the end of week 10, serum concentrations of glucose, carboxymethyl lysine, pentosidine, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1), and sE-selectin were measured after a 12- to 14-h fast. Results Serum fasting glucose decreased significantly up to 20% in the ginger group at the end of week 10 compared with baseline ( P  
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2014.11.020