Quinoxaline, its derivatives and applications: A State of the Art review

Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perfo...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2015-06, Vol.97, p.664-672
Main Authors: Pereira, Joana A., Pessoa, Ana M., Cordeiro, M. Natália D.S., Fernandes, Rúben, Prudêncio, Cristina, Noronha, João Paulo, Vieira, Mónica
Format: Article
Language:English
Subjects:
Animals
Biological activity
Biomedical applications
Chronic Disease - drug therapy
Drug Discovery - methods
Humans
Metabolic Diseases - drug therapy
Quinoxaline
Quinoxaline derivatives
Quinoxalines - chemistry
Quinoxalines - pharmacology
Quinoxalines - therapeutic use
Therapeutic application
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Summary:Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment. [Display omitted] •Quinoxaline and its' derivatives are compounds with multiple potential applications.•We present biological applications of quinoxaline and derivatives already studied.•Quinoxaline based compounds are of great medicinal–biological interest.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2014.06.058