Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis

Highlights • Parkinson's disease (PD) proteins deregulate protein translation processes. • We propose a hypothesis linking cell survival to protein translation control in PD. • The hypothesis has implications for the development of PD diagnostics and therapies.

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Bibliographic Details
Published in:Trends in molecular medicine 2015-08, Vol.21 (8), p.466-472
Main Authors: Taymans, Jean-Marc, Nkiliza, Aurore, Chartier-Harlin, Marie-Christine
Format: Article
Language:English
Subjects:
alpha-synuclein
EIF4G1
Gene Expression Regulation
Genetic Association Studies
Genetic Predisposition to Disease
Humans
LRRK2
Parkinson Disease - genetics
Parkinson Disease - metabolism
Pathology
Protein Biosynthesis
ribosome
translation elongation factor
translation initiation factor
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Description
Summary:Highlights • Parkinson's disease (PD) proteins deregulate protein translation processes. • We propose a hypothesis linking cell survival to protein translation control in PD. • The hypothesis has implications for the development of PD diagnostics and therapies.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2015.05.004