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XRCC1 polymorphisms associated with survival among Chinese bladder cancer patients receiving epirubicin and mitomycin C
The association between DNA repair gene polymorphisms and bladder cancer risk has been widely studied. However, only few studies have examined the correlation between bladder cancer and instillation agent sensitivity. The aim of this study was to examine the association between polymorphisms of DNA...
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Published in: | Tumor biology 2015-06, Vol.36 (6), p.4591-4596 |
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description | The association between DNA repair gene polymorphisms and bladder cancer risk has been widely studied. However, only few studies have examined the correlation between bladder cancer and instillation agent sensitivity. The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I (
XRCC1
) rs2854509 and rs3213255, and bladder cancer recurrence risk. We recruited 244 patients (130 treated with epirubicin and 114 treated with mitomycin C). Genomic DNA was used to examine the
XRCC1
rs2854509 and rs3213255 genotypes by Taqman PCR analysis. Combination analysis of
XRCC1
rs2854509 and rs3213255 and examination of
XRCC1
diplotypes were performed to reveal possible correlations. The rs2854509 CC and rs3213255 TT genotypes conferred shorter survival times than the rs2854509 AC/AA and rs3213255 CC/CT genotypes in patients treated with epirubicin, but not in those treated with mitomycin C (MMC) in adjusted models [hazard ratio (HR) = 0.23, 95 % confidence interval (CI) = 0.10–0.53 for rs2854509 AC + AA compared with CC; HR = 0.17, 95 % CI = 0.06–0.46 for rs3213255 CC + CT compared with TT]. Combination analysis showed significantly increased recurrence-free survival (RFS) among patients simultaneously carrying the rs2854509 AC/AA and rs3213255 CC/CT genotypes with an HR of 0.15 (95 % CI = 0.05–0.45) compared to those carrying other genotypes. Diplotype analysis demonstrated that the A-C/C-T diplotype is associated with a lower risk of recurrence compared with the common wild C-T/C-T diplotype (HR = 0.17, 95 % CI = 0.06–0.51). Our results suggest that the rs2854509 CC and rs3213255 TT genotypes confer higher sensitivity to epirubicin instillation. Moreover, the A-C/C-T diplotype presents significantly lower recurrence risk than other diplotypes. |
doi_str_mv | 10.1007/s13277-015-3104-0 |
format | article |
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XRCC1
) rs2854509 and rs3213255, and bladder cancer recurrence risk. We recruited 244 patients (130 treated with epirubicin and 114 treated with mitomycin C). Genomic DNA was used to examine the
XRCC1
rs2854509 and rs3213255 genotypes by Taqman PCR analysis. Combination analysis of
XRCC1
rs2854509 and rs3213255 and examination of
XRCC1
diplotypes were performed to reveal possible correlations. The rs2854509 CC and rs3213255 TT genotypes conferred shorter survival times than the rs2854509 AC/AA and rs3213255 CC/CT genotypes in patients treated with epirubicin, but not in those treated with mitomycin C (MMC) in adjusted models [hazard ratio (HR) = 0.23, 95 % confidence interval (CI) = 0.10–0.53 for rs2854509 AC + AA compared with CC; HR = 0.17, 95 % CI = 0.06–0.46 for rs3213255 CC + CT compared with TT]. Combination analysis showed significantly increased recurrence-free survival (RFS) among patients simultaneously carrying the rs2854509 AC/AA and rs3213255 CC/CT genotypes with an HR of 0.15 (95 % CI = 0.05–0.45) compared to those carrying other genotypes. Diplotype analysis demonstrated that the A-C/C-T diplotype is associated with a lower risk of recurrence compared with the common wild C-T/C-T diplotype (HR = 0.17, 95 % CI = 0.06–0.51). Our results suggest that the rs2854509 CC and rs3213255 TT genotypes confer higher sensitivity to epirubicin instillation. Moreover, the A-C/C-T diplotype presents significantly lower recurrence risk than other diplotypes.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-015-3104-0</identifier><identifier>PMID: 25616696</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Alleles ; Biomarkers, Pharmacological ; Biomedical and Life Sciences ; Biomedicine ; Bladder cancer ; Cancer Research ; China ; Disease-Free Survival ; DNA repair ; DNA-Binding Proteins - genetics ; Epirubicin - administration & dosage ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype & phenotype ; Humans ; Male ; Middle Aged ; Mitomycin - administration & dosage ; Polymorphism ; Polymorphism, Single Nucleotide ; Research Article ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery ; X-ray Repair Cross Complementing Protein 1</subject><ispartof>Tumor biology, 2015-06, Vol.36 (6), p.4591-4596</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5161017b4095c2d71c9e79821b617ee15f5eecf7be73993b7be0a6bbf85f4c773</citedby><cites>FETCH-LOGICAL-c442t-5161017b4095c2d71c9e79821b617ee15f5eecf7be73993b7be0a6bbf85f4c773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1702210711?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25616696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Xiaheng</creatorcontrib><creatorcontrib>Zhang, Xiaolei</creatorcontrib><creatorcontrib>Cheng, Yidong</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Zhao, Ruizhe</creatorcontrib><creatorcontrib>Liu, Xuzhong</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Qin, Chao</creatorcontrib><creatorcontrib>Lu, Qiang</creatorcontrib><creatorcontrib>Yin, Changjun</creatorcontrib><title>XRCC1 polymorphisms associated with survival among Chinese bladder cancer patients receiving epirubicin and mitomycin C</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>The association between DNA repair gene polymorphisms and bladder cancer risk has been widely studied. However, only few studies have examined the correlation between bladder cancer and instillation agent sensitivity. The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I (
XRCC1
) rs2854509 and rs3213255, and bladder cancer recurrence risk. We recruited 244 patients (130 treated with epirubicin and 114 treated with mitomycin C). Genomic DNA was used to examine the
XRCC1
rs2854509 and rs3213255 genotypes by Taqman PCR analysis. Combination analysis of
XRCC1
rs2854509 and rs3213255 and examination of
XRCC1
diplotypes were performed to reveal possible correlations. The rs2854509 CC and rs3213255 TT genotypes conferred shorter survival times than the rs2854509 AC/AA and rs3213255 CC/CT genotypes in patients treated with epirubicin, but not in those treated with mitomycin C (MMC) in adjusted models [hazard ratio (HR) = 0.23, 95 % confidence interval (CI) = 0.10–0.53 for rs2854509 AC + AA compared with CC; HR = 0.17, 95 % CI = 0.06–0.46 for rs3213255 CC + CT compared with TT]. Combination analysis showed significantly increased recurrence-free survival (RFS) among patients simultaneously carrying the rs2854509 AC/AA and rs3213255 CC/CT genotypes with an HR of 0.15 (95 % CI = 0.05–0.45) compared to those carrying other genotypes. Diplotype analysis demonstrated that the A-C/C-T diplotype is associated with a lower risk of recurrence compared with the common wild C-T/C-T diplotype (HR = 0.17, 95 % CI = 0.06–0.51). Our results suggest that the rs2854509 CC and rs3213255 TT genotypes confer higher sensitivity to epirubicin instillation. Moreover, the A-C/C-T diplotype presents significantly lower recurrence risk than other diplotypes.</description><subject>Aged</subject><subject>Alleles</subject><subject>Biomarkers, Pharmacological</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bladder cancer</subject><subject>Cancer Research</subject><subject>China</subject><subject>Disease-Free Survival</subject><subject>DNA repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Epirubicin - administration & dosage</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitomycin - administration & dosage</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Research Article</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>X-ray Repair Cross Complementing Protein 1</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kUFr3DAQhUVJadK0PyCXIuilF7cayZbWx2CSthAolBZ6E5I8zirYkiPZG_bfV9tNSinkNG_QN0_SPEIugH0ExtSnDIIrVTFoKgGsrtgLcgY1FxUTG3ZSNANW1XwjTsnrnO9YAdtWviKnvJEgZSvPyMOv710HdI7jfopp3vo8ZWpyjs6bBXv64JctzWva-Z0ZqZliuKXd1gfMSO1o-h4TdSa4UmazeAxLpgkd-p0vJM4-rdY7H6gJPZ38Eqf9oevekJeDGTO-fazn5Of11Y_uS3Xz7fPX7vKmcnXNl6oBWT6hbM3axvFegWtRtRsOVoJChGZoEN2gLCrRtsIWwYy0dtg0Q-2UEufkw9F3TvF-xbzoyWeH42gCxjVrUIzLhoM4oO__Q-_imkJ53R-KA1MAhYIj5VLMOeGg5-Qnk_YamD6koo-p6LJsfUhFszLz7tF5tRP2fyeeYigAPwK5HIVbTP9c_azrbyE7mGI</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Deng, Xiaheng</creator><creator>Zhang, Xiaolei</creator><creator>Cheng, Yidong</creator><creator>Yang, Xiao</creator><creator>Zhao, Ruizhe</creator><creator>Liu, Xuzhong</creator><creator>Li, Xiao</creator><creator>Qin, Chao</creator><creator>Lu, Qiang</creator><creator>Yin, Changjun</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>XRCC1 polymorphisms associated with survival among Chinese bladder cancer patients receiving epirubicin and mitomycin C</title><author>Deng, Xiaheng ; Zhang, Xiaolei ; Cheng, Yidong ; Yang, Xiao ; Zhao, Ruizhe ; Liu, Xuzhong ; Li, Xiao ; Qin, Chao ; Lu, Qiang ; Yin, Changjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5161017b4095c2d71c9e79821b617ee15f5eecf7be73993b7be0a6bbf85f4c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Biomarkers, Pharmacological</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bladder cancer</topic><topic>Cancer Research</topic><topic>China</topic><topic>Disease-Free Survival</topic><topic>DNA repair</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Epirubicin - administration & dosage</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitomycin - administration & dosage</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Research Article</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>X-ray Repair Cross Complementing Protein 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Xiaheng</creatorcontrib><creatorcontrib>Zhang, Xiaolei</creatorcontrib><creatorcontrib>Cheng, Yidong</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Zhao, Ruizhe</creatorcontrib><creatorcontrib>Liu, Xuzhong</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Qin, Chao</creatorcontrib><creatorcontrib>Lu, Qiang</creatorcontrib><creatorcontrib>Yin, Changjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Xiaheng</au><au>Zhang, Xiaolei</au><au>Cheng, Yidong</au><au>Yang, Xiao</au><au>Zhao, Ruizhe</au><au>Liu, Xuzhong</au><au>Li, Xiao</au><au>Qin, Chao</au><au>Lu, Qiang</au><au>Yin, Changjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>XRCC1 polymorphisms associated with survival among Chinese bladder cancer patients receiving epirubicin and mitomycin C</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>36</volume><issue>6</issue><spage>4591</spage><epage>4596</epage><pages>4591-4596</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>The association between DNA repair gene polymorphisms and bladder cancer risk has been widely studied. However, only few studies have examined the correlation between bladder cancer and instillation agent sensitivity. The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I (
XRCC1
) rs2854509 and rs3213255, and bladder cancer recurrence risk. We recruited 244 patients (130 treated with epirubicin and 114 treated with mitomycin C). Genomic DNA was used to examine the
XRCC1
rs2854509 and rs3213255 genotypes by Taqman PCR analysis. Combination analysis of
XRCC1
rs2854509 and rs3213255 and examination of
XRCC1
diplotypes were performed to reveal possible correlations. The rs2854509 CC and rs3213255 TT genotypes conferred shorter survival times than the rs2854509 AC/AA and rs3213255 CC/CT genotypes in patients treated with epirubicin, but not in those treated with mitomycin C (MMC) in adjusted models [hazard ratio (HR) = 0.23, 95 % confidence interval (CI) = 0.10–0.53 for rs2854509 AC + AA compared with CC; HR = 0.17, 95 % CI = 0.06–0.46 for rs3213255 CC + CT compared with TT]. Combination analysis showed significantly increased recurrence-free survival (RFS) among patients simultaneously carrying the rs2854509 AC/AA and rs3213255 CC/CT genotypes with an HR of 0.15 (95 % CI = 0.05–0.45) compared to those carrying other genotypes. Diplotype analysis demonstrated that the A-C/C-T diplotype is associated with a lower risk of recurrence compared with the common wild C-T/C-T diplotype (HR = 0.17, 95 % CI = 0.06–0.51). Our results suggest that the rs2854509 CC and rs3213255 TT genotypes confer higher sensitivity to epirubicin instillation. Moreover, the A-C/C-T diplotype presents significantly lower recurrence risk than other diplotypes.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>25616696</pmid><doi>10.1007/s13277-015-3104-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Alleles Biomarkers, Pharmacological Biomedical and Life Sciences Biomedicine Bladder cancer Cancer Research China Disease-Free Survival DNA repair DNA-Binding Proteins - genetics Epirubicin - administration & dosage Female Genetic Association Studies Genetic Predisposition to Disease Genotype & phenotype Humans Male Middle Aged Mitomycin - administration & dosage Polymorphism Polymorphism, Single Nucleotide Research Article Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery X-ray Repair Cross Complementing Protein 1 |
title | XRCC1 polymorphisms associated with survival among Chinese bladder cancer patients receiving epirubicin and mitomycin C |
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