Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis

Objective Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation. Materials and Methods Thirty‐four healthy adults were randomized to recei...

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Bibliographic Details
Published in:Oral diseases 2015-09, Vol.21 (6), p.705-712
Main Authors: Lee, J-K, Kim, S-J, Ko, S-H, Ouwehand, AC, Ma, DS
Format: Article
Language:English
Subjects:
Dental Plaque Index
Dentistry
Dinoprostone - metabolism
Double-Blind Method
Female
gingival crevicular fluid
Gingival Crevicular Fluid - metabolism
gingivitis
Gingivitis - metabolism
Gingivitis - prevention & control
Gum disease
Humans
Lactobacillus brevis
Male
Nitric oxide
Nitric Oxide - metabolism
Periodontal Index
Probiotics
Probiotics - therapeutic use
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Summary:Objective Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation. Materials and Methods Thirty‐four healthy adults were randomized to receive L. brevisCD2 lozenges or placebo, three times daily for 14 days. The subjects refrained from oral hygiene, the extent of which was determined at various time points. Results In both groups, bleeding on probing scores increased continuously throughout the study except on day 3. In the placebo group, scores increased significantly from 9.50 at baseline to 14.75 and 14.81 on days 10 and 14, respectively (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12332