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Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis
Objective Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation. Materials and Methods Thirty‐four healthy adults were randomized to recei...
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| Published in: | Oral diseases 2015-09, Vol.21 (6), p.705-712 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 712 |
| container_issue | 6 |
| container_start_page | 705 |
| container_title | Oral diseases |
| container_volume | 21 |
| creator | Lee, J-K Kim, S-J Ko, S-H Ouwehand, AC Ma, DS |
| description | Objective
Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation.
Materials and Methods
Thirty‐four healthy adults were randomized to receive L. brevisCD2 lozenges or placebo, three times daily for 14 days. The subjects refrained from oral hygiene, the extent of which was determined at various time points.
Results
In both groups, bleeding on probing scores increased continuously throughout the study except on day 3. In the placebo group, scores increased significantly from 9.50 at baseline to 14.75 and 14.81 on days 10 and 14, respectively (P |
| doi_str_mv | 10.1111/odi.12332 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1702652151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3770992771</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3872-5dde26fdba1c5324d8dce5b468929514f38df05a0872c5b305fc5e7c48c3f47a3</originalsourceid><addsrcrecordid>eNpdkU1PwzAMhiME4vvAH0CRuHAp5KNpuyOMT2kMJEDsFtLEZRldM5oU2L8nbMABX2zJz2vZfhHao-SIxjh2xh5RxjlbQZs0IzQhBROrseYiTQTjow205f2EEJr3OFtHG0zkjGRUbKLnG2e6WgXrGuwqHMaAx84H3IKfucYDLud41rrSumA1HigdXKm0revO47KFd-tx_4xh22D4nEFrp9AEVeMX27zYdxus30Frlao97P7kbfR4cf7Qv0oGt5fX_ZNBYnmRs0QYAyyrTKmoFpylpjAaRJlmRY_1BE0rXpiKCEUirEXJiai0gFynheZVmiu-jQ6Xc-O2bx34IKfWa6hr1YDrvKQ5YZlgVNCIHvxDJ65rm7jdgqLxTSmL1P4P1ZVTMHIWj1PtXP7-LgLHS-DD1jD_61Miv02R0RS5MEXenl0viqhIlgrrA3z-KVT7KrOc50I-DS_lqDi9v-vxKznkX3BAjYM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1702101742</pqid></control><display><type>article</type><title>Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Lee, J-K ; Kim, S-J ; Ko, S-H ; Ouwehand, AC ; Ma, DS</creator><creatorcontrib>Lee, J-K ; Kim, S-J ; Ko, S-H ; Ouwehand, AC ; Ma, DS</creatorcontrib><description>Objective
Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation.
Materials and Methods
Thirty‐four healthy adults were randomized to receive L. brevisCD2 lozenges or placebo, three times daily for 14 days. The subjects refrained from oral hygiene, the extent of which was determined at various time points.
Results
In both groups, bleeding on probing scores increased continuously throughout the study except on day 3. In the placebo group, scores increased significantly from 9.50 at baseline to 14.75 and 14.81 on days 10 and 14, respectively (P < 0.05). No significant change from baseline was observed in the CD2 group. However, scores were consistently higher with placebo, and significant intergroup differences were observed on day 10. Plaque and gingival indices increased from baseline in both treatment groups, but no intergroup differences were observed. Measurements of immune markers in gingival crevicular fluid revealed increased production of nitric oxide in the placebo group (P < 0.05). Prostaglandin E2 production decreased over time in both groups.
Conclusion
Lactobacillus brevisCD2 may delay gingivitis development in this model by downregulating an inflammatory cascade.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12332</identifier><identifier>PMID: 25720615</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Dental Plaque Index ; Dentistry ; Dinoprostone - metabolism ; Double-Blind Method ; Female ; gingival crevicular fluid ; Gingival Crevicular Fluid - metabolism ; gingivitis ; Gingivitis - metabolism ; Gingivitis - prevention & control ; Gum disease ; Humans ; Lactobacillus brevis ; Male ; Nitric oxide ; Nitric Oxide - metabolism ; Periodontal Index ; Probiotics ; Probiotics - therapeutic use</subject><ispartof>Oral diseases, 2015-09, Vol.21 (6), p.705-712</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1710-1580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25720615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, J-K</creatorcontrib><creatorcontrib>Kim, S-J</creatorcontrib><creatorcontrib>Ko, S-H</creatorcontrib><creatorcontrib>Ouwehand, AC</creatorcontrib><creatorcontrib>Ma, DS</creatorcontrib><title>Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation.
Materials and Methods
Thirty‐four healthy adults were randomized to receive L. brevisCD2 lozenges or placebo, three times daily for 14 days. The subjects refrained from oral hygiene, the extent of which was determined at various time points.
Results
In both groups, bleeding on probing scores increased continuously throughout the study except on day 3. In the placebo group, scores increased significantly from 9.50 at baseline to 14.75 and 14.81 on days 10 and 14, respectively (P < 0.05). No significant change from baseline was observed in the CD2 group. However, scores were consistently higher with placebo, and significant intergroup differences were observed on day 10. Plaque and gingival indices increased from baseline in both treatment groups, but no intergroup differences were observed. Measurements of immune markers in gingival crevicular fluid revealed increased production of nitric oxide in the placebo group (P < 0.05). Prostaglandin E2 production decreased over time in both groups.
Conclusion
Lactobacillus brevisCD2 may delay gingivitis development in this model by downregulating an inflammatory cascade.</description><subject>Dental Plaque Index</subject><subject>Dentistry</subject><subject>Dinoprostone - metabolism</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>gingival crevicular fluid</subject><subject>Gingival Crevicular Fluid - metabolism</subject><subject>gingivitis</subject><subject>Gingivitis - metabolism</subject><subject>Gingivitis - prevention & control</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Lactobacillus brevis</subject><subject>Male</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Periodontal Index</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpdkU1PwzAMhiME4vvAH0CRuHAp5KNpuyOMT2kMJEDsFtLEZRldM5oU2L8nbMABX2zJz2vZfhHao-SIxjh2xh5RxjlbQZs0IzQhBROrseYiTQTjow205f2EEJr3OFtHG0zkjGRUbKLnG2e6WgXrGuwqHMaAx84H3IKfucYDLud41rrSumA1HigdXKm0revO47KFd-tx_4xh22D4nEFrp9AEVeMX27zYdxus30Frlao97P7kbfR4cf7Qv0oGt5fX_ZNBYnmRs0QYAyyrTKmoFpylpjAaRJlmRY_1BE0rXpiKCEUirEXJiai0gFynheZVmiu-jQ6Xc-O2bx34IKfWa6hr1YDrvKQ5YZlgVNCIHvxDJ65rm7jdgqLxTSmL1P4P1ZVTMHIWj1PtXP7-LgLHS-DD1jD_61Miv02R0RS5MEXenl0viqhIlgrrA3z-KVT7KrOc50I-DS_lqDi9v-vxKznkX3BAjYM</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Lee, J-K</creator><creator>Kim, S-J</creator><creator>Ko, S-H</creator><creator>Ouwehand, AC</creator><creator>Ma, DS</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1710-1580</orcidid></search><sort><creationdate>201509</creationdate><title>Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis</title><author>Lee, J-K ; Kim, S-J ; Ko, S-H ; Ouwehand, AC ; Ma, DS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3872-5dde26fdba1c5324d8dce5b468929514f38df05a0872c5b305fc5e7c48c3f47a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Dental Plaque Index</topic><topic>Dentistry</topic><topic>Dinoprostone - metabolism</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>gingival crevicular fluid</topic><topic>Gingival Crevicular Fluid - metabolism</topic><topic>gingivitis</topic><topic>Gingivitis - metabolism</topic><topic>Gingivitis - prevention & control</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Lactobacillus brevis</topic><topic>Male</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Periodontal Index</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, J-K</creatorcontrib><creatorcontrib>Kim, S-J</creatorcontrib><creatorcontrib>Ko, S-H</creatorcontrib><creatorcontrib>Ouwehand, AC</creatorcontrib><creatorcontrib>Ma, DS</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, J-K</au><au>Kim, S-J</au><au>Ko, S-H</au><au>Ouwehand, AC</au><au>Ma, DS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2015-09</date><risdate>2015</risdate><volume>21</volume><issue>6</issue><spage>705</spage><epage>712</epage><pages>705-712</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
Probiotic Lactobacillus brevisCD2 (CD2) exerts anti‐inflammatory properties by preventing nitric oxide synthesis. It is hypothesized that oral application of CD2 can inhibit naturally occurring gingival inflammation.
Materials and Methods
Thirty‐four healthy adults were randomized to receive L. brevisCD2 lozenges or placebo, three times daily for 14 days. The subjects refrained from oral hygiene, the extent of which was determined at various time points.
Results
In both groups, bleeding on probing scores increased continuously throughout the study except on day 3. In the placebo group, scores increased significantly from 9.50 at baseline to 14.75 and 14.81 on days 10 and 14, respectively (P < 0.05). No significant change from baseline was observed in the CD2 group. However, scores were consistently higher with placebo, and significant intergroup differences were observed on day 10. Plaque and gingival indices increased from baseline in both treatment groups, but no intergroup differences were observed. Measurements of immune markers in gingival crevicular fluid revealed increased production of nitric oxide in the placebo group (P < 0.05). Prostaglandin E2 production decreased over time in both groups.
Conclusion
Lactobacillus brevisCD2 may delay gingivitis development in this model by downregulating an inflammatory cascade.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>25720615</pmid><doi>10.1111/odi.12332</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1710-1580</orcidid></addata></record> |
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| identifier | ISSN: 1354-523X |
| ispartof | Oral diseases, 2015-09, Vol.21 (6), p.705-712 |
| issn | 1354-523X 1601-0825 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Dental Plaque Index Dentistry Dinoprostone - metabolism Double-Blind Method Female gingival crevicular fluid Gingival Crevicular Fluid - metabolism gingivitis Gingivitis - metabolism Gingivitis - prevention & control Gum disease Humans Lactobacillus brevis Male Nitric oxide Nitric Oxide - metabolism Periodontal Index Probiotics Probiotics - therapeutic use |
| title | Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis |
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