Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis

Background Vitamin D is a multifunctional pro-hormone and has widespread actions in human body. Several studies showed a possible association between vitamin D deficiency and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes, but no definite conclusion was available. Methods A sy...

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Published in:Journal of endocrinological investigation 2015-05, Vol.38 (5), p.513-518
Main Authors: Lv, W. S., Zhao, W. J., Gong, S. L., Fang, D. D., Wang, B., Fu, Z. J., Yan, S. L., Wang, Y. G.
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 2 - blood
Diabetic Neuropathies - blood
Endocrinology
Humans
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:Background Vitamin D is a multifunctional pro-hormone and has widespread actions in human body. Several studies showed a possible association between vitamin D deficiency and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes, but no definite conclusion was available. Methods A systematic review and meta-analysis was performed to comprehensively assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and DPN in patients with type 2 diabetes. Data from eligible studies were pooled using meta-analysis. Results Six studies that involved a total of 1,484 type 2 diabetic patients were finally included into the meta-analysis. Meta-analysis showed that there were obviously decreased serum 25(OH)D levels in DPN patients [weighted mean difference (WMD) = −6.36 ng/ml, 95 % confidence interval (95 % CI) −8.57 to −4.14, P  
ISSN:1720-8386
1720-8386
DOI:10.1007/s40618-014-0210-6